The Enzymatic Degradation of Heme Proteins into Bite Pigments.
نویسندگان
چکیده
منابع مشابه
The Enzymatic Degradation of Hemoglobin to Bile Pigments by Macrophages
Recent studies have identified and characterized the enzymatic mechanism by which hemoglobin-heme is converted to bilirubin. Under physiologic conditions the enzyme system, microsomal heme-oxygenase, is most active in the spleen followed by the liver and bone marrow, all of which are tissues that normally are involved in the sequestration and metabolism of red cells. Indirect evidence suggested...
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Background: Malaria parasites detoxify copious amounts of heme during human infection but enzyme involvement remains unclear. Results: Parasite-infected and uninfected erythrocytes contain indistinguishable low levels of heme catabolites, and a heme oxygenase-like parasite protein binds but does not degrade heme. Conclusion: P. falciparum parasites do not enzymatically degrade heme. Significanc...
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Malaria parasites generate vast quantities of heme during blood stage infection via hemoglobin digestion and limited de novo biosynthesis, but it remains unclear if parasites metabolize heme for utilization or disposal. Recent in vitro experiments with a heme oxygenase (HO)-like protein from Plasmodium falciparum suggested that parasites may enzymatically degrade some heme to the canonical HO p...
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The effect of plasma on degradation of human growth hormonereleasing hormone (GRH) was examined in vitro and in vivo using high performance liquid chromatography (HPLC), radioimmunoassay (RIA), and bioassay. When GRH(1-44)-NH2 was incubated with human plasma, the t1/2 of total GRH immunoreactivity was 63 min (RIA). However, HPLC revealed a more rapid disappearance (t1/2, 17 min) ofGRH(144)-NH2 ...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1961
ISSN: 0021-4280
DOI: 10.2183/pjab1945.37.643